Where was the first successful American winery located? The answer is Cincinnati, Ohio. In the mid-1830s a winery owned by Nicholas Longworth made sparkling wine from Catawba grapes. By the 1850s he was producing 100,000 bottles a year with distribution to Europe and across the U.S. Unfortunately, by the 1860s, black rot and downy mildew struck heavily in the Ohio Vineyards. Little by little this prompted many up and coming winemakers to move to the Fingerlakes region in New York, which continues to thrive. Missouri also had a large wine region in the mid to late 1800s and was second only to California in wine production by the end of the century.